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anti-OPNc phosphothioate oligomer
- Development stage
- Preclinical
- Lead developer
- Instituto Nacional de Câncer
- Modality
- MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Parenteral
01
Overview
anti-OPNc phosphothioate oligomer is a phosphorothioate-modified antisense DNA oligonucleotide (ASO) designed to selectively knock down the expression of osteopontin-c (OPNc), a splice variant of osteopontin (SPP1). Developed by researchers at the National Cancer Institute (INCA) in Brazil, this oligomer is used as a preclinical research tool to investigate the role of OPNc in mediating chemoresistance, cell survival, and epithelial-mesenchymal transition (EMT) in various cancer models, including breast cancer, ovarian cancer, and B-cell acute lymphoblastic leukemia (B-ALL). By silencing OPNc, the oligomer downregulates P-glycoprotein (P-gp) expression and sensitizes drug-resistant cancer cells to chemotherapeutic agents such as doxorubicin and cisplatin.
- Other names
- anti-OPNc ASOanti-OPNc antisense oligonucleotideanti-OPNc phosphorothioate-modified antisense DNA oligomeranti-OPNc phosphorothiotate-modified antisense DNA oligomeranti-OPNc phosphothiotate-modified DNA oligomerASO anti-OPNc
02
Targets
SPP1 (Osteopontin)
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