anti-PfRH5 monoclonal antibodies

Anti-PfRH5 monoclonal antibodies are a group of research-stage monoclonal antibodies targeting the *Plasmodium falciparum* reticulocyte-binding protein homolog 5 (PfRH5), an essential blood-stage parasite adhesin. PfRH5 forms a trimeric complex with cysteine-rich protective antigen (PfCyRPA) and PfRH5-interacting protein (PfRIPR) to bind the host erythrocyte receptor basigin (CD147), a critical step for merozoite invasion. By binding to PfRH5, these antibodies block its interaction with basigin, thereby neutralizing merozoite invasion and preventing or treating blood-stage malaria. Various academic institutions have developed different antibody clones (such as 5A08, c2AC7, and c4BA7) to evaluate their neutralizing capacity, map protective epitopes, and guide next-generation malaria vaccine design.

Other names

2E115A035A089AD4R5.016R-5.016R 5.016anti-PfRH5 mAbsanti-PfRH-5 mAbsanti-PfRH 5 mAbsanti-PfRH5 monoclonal antibodyanti-PfRH-5 monoclonal antibodyanti-PfRH 5 monoclonal antibodyanti-RH5 mAbsanti-RH-5 mAbsanti-RH 5 mAbsanti-RH5 monoclonal antibodiesanti-RH-5 monoclonal antibodiesanti-RH 5 monoclonal antibodiesanti-RH5 monoclonal antibodyanti-RH-5 monoclonal antibodyanti-RH 5 monoclonal antibodyc2AC7c-2AC7c 2AC7c4BA7c-4BA7c 4BA7c9AD4c-9AD4c 9AD4