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anti-pseudomonas antibodies-University Hospital, Grenoble

Development stage
Preclinical
Lead developer
Epynext Therapeutics
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Intravenous, Intratracheal
01

Overview

Anti-pseudomonas antibodies-University Hospital, Grenoble is a research program led by the University Hospital, Grenoble (Centre Hospitalier Universitaire de Grenoble) focused on the development of human monoclonal antibodies for the treatment of Pseudomonas aeruginosa infections. The program utilizes a prospective study to isolate therapeutic antibodies from the B lymphocytes of patients, particularly those with cystic fibrosis, who have been previously infected or colonized by the pathogen. These recombinant biologics are designed to provide an alternative to conventional antibiotics, specifically targeting multi-drug resistant (MDR) strains that are prevalent in hospital settings. The research aims to identify functional antibodies from patient sera and clone them to produce effective anti-infective therapies.

Other names
human monoclonal anti-Pseudomonas antibodiesanti-Pseudomonas aeruginosa antibodies
02

Targets

PcrV (Type III secretion protein PcrV)PscF (Type III secretion system needle protein PscF)OprF (Outer membrane protein F)

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