Drug intelligence / Profile preview

anti-SARS-CoV-2 immunoglobulins (bovine colostrum)

Development stage
Phase 2
Lead developer
Razi Vaccine & Serum Research Institute
Modality
Antibody-Based Therapeutics
Administration
Oral, Intravenous, Intranasal
01

Overview

**Anti-SARS-CoV-2 immunoglobulins (bovine colostrum)** are polyclonal antibodies specifically targeting SARS-CoV-2, derived from the colostrum of cows vaccinated with SARS-CoV-2 antigens[7][5][1]. These immunoglobulins act by binding to SARS-CoV-2 virions, blocking viral entry into host cells, and facilitating neutralization of the pathogen[7][5]. The colostrum of immunized cows is collected post-parturition and contains high concentrations of SARS-CoV-2-specific IgG (and other immunoglobulins), which can be administered orally, intranasally, or intravenously to confer passive immunity[7][5][4]. Mechanistically, these antibodies provide direct viral neutralization, potential prevention of infection, and immune modulation. This approach is under investigation as an adjunctive or prophylactic therapy for COVID-19, with demonstrated virus-neutralizing activity in vitro and initial human safety data (phase 1)[7][5][4].

Brand names
BioBlock
Other names
anti-COVID-19 hyperimmune immunoglobulins (bovine colostrum)hyperimmune bovine colostrum immunoglobulinsSARS-CoV-2-neutralizing antibodies (bovine colostrum)hyper-immune bovine colostrum
02

Targets

ACE2 (Angiotensin-converting enzyme 2)SARS-CoV-2 spike

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