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anti-SDCBP IgG4
- Development stage
- Preclinical
- Lead developer
- University of Chicago
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
anti-SDCBP IgG4 is a recombinant monoclonal antibody of the IgG4 subclass designed to target Syntenin-1, a protein encoded by the SDCBP gene. Syntenin-1 acts as a scaffold protein involved in exosome biogenesis, syndecan signaling, and cancer cell metastasis. This antibody was identified as a naturally occurring, protective autoantibody in patients with endometriosis and ovarian cancer. By binding to Syntenin-1, the antibody inhibits its pro-tumorigenic functions, thereby antagonizing malignant progression. It is being explored as a potential immunotherapy for ovarian carcinoma and other Syntenin-1-overexpressing tumors.
- Other names
- anti-Syntenin-1 IgG4anti-Syntenin1 IgG4anti-Syntenin 1 IgG4Syntenin-1 IgG4 antibodySyntenin1 IgG4 antibodySyntenin 1 IgG4 antibody
02
Targets
SDCBP (Syntenin-1)
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