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Drug intelligence / Profile preview
anti-SELE antibody
- Development stage
- Preclinical
- Lead developer
- UCB
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
An anti-SELE antibody is a monoclonal antibody designed to target E-selectin (SELE, CD62E), a cell adhesion molecule transiently expressed on vascular endothelial cells in response to inflammatory cytokines. By binding to E-selectin, the antibody blocks its interaction with ligands such as CD44 or sialyl Lewis X (sLeX) on circulating cells. This disruption inhibits leukocyte adhesion and extravasation, which is relevant in inflammatory diseases like psoriasis and rheumatoid arthritis, as well as in sickle cell disease vaso-occlusive crises. In oncology, targeting the SELE-CD44 axis on endothelial cells can suppress tumor cell proliferation, metastasis, and chemotherapy resistance, making anti-SELE antibodies potential therapeutic candidates or adjuncts to chemotherapy.
- Other names
- anti-CD62E antibodyanti-CD-62E antibodyanti-CD 62E antibodyanti-E-selectin antibodyE-selectin antibodySELE antibody
02
Targets
SELE (E-selectin)
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