Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
anti-SIRPα antibody (clone 6F2)
- Development stage
- Preclinical
- Lead developer
- Genentech
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intraperitoneal, Subcutaneous
01
Overview
anti-SIRPα antibody (clone 6F2) is a high-affinity, agonistic monoclonal antibody that targets mouse signal regulatory protein alpha (SIRPα). Developed by Genentech, this antibody is used in preclinical research to investigate the therapeutic potential of SIRPα receptor agonism in chronic inflammatory and autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel disease (colitis), and cardiac allograft rejection. By binding to SIRPα, clone 6F2 induces receptor phosphorylation and downstream inhibitory signaling, which suppresses myeloid cell activation, reduces neutrophil and monocyte chemotaxis, and inhibits their migration and infiltration into inflamed tissues.
- Other names
- agonist anti-mouse SIRPα (clone 6F2)agonistic anti-SIRPα antibody (clone 6F2)anti-SIRPα (clone 6F2)
02
Targets
CD47 (Cluster of Differentiation 47)SIRPA (Signal-regulatory protein alpha)SIRPB1 (Signal-regulatory protein beta-1)SIRPG (Signal-regulatory protein gamma)
Beyond the preview
Go deeper on anti-SIRPα antibody (clone 6F2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on anti-SIRPα antibody (clone 6F2).