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anti-t-lymphocyte globulin (rabbit)
- Development stage
- Unknown
- Lead developer
- Neovii Pharmaceuticals
- Modality
- Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
IIT-ATLG-64 refers to a clinical development program by Neovii Pharmaceuticals involving **anti-t-lymphocyte globulin (rabbit)**, commercially known as **Grafalon**. Grafalon is a rabbit-derived polyclonal antibody preparation directed against a broad spectrum of human T-lymphocyte surface antigens. Its primary mechanism of action involves the depletion of peripheral T-lymphocytes through complement-dependent cytotoxicity and opsonization, as well as the modulation of T-cell function and induction of apoptosis in activated T-cells. The IIT-ATLG-64 program is specifically focused on the use of this agent in the context of **stem cell transplantation (SCT)**, particularly for the prophylaxis of graft-versus-host disease (GvHD). The designation "IIT" indicates that this specific development path is being pursued through an investigator-initiated trial framework supported by Neovii, with the program currently listed in Phase 3 for SCT indications.
- Brand names
- Grafalon
- Other names
- anti-human T-lymphocyte globulin (rabbit)ATG-Fresenius
02
Targets
CD2 (T-cell Surface Antigen CD2)CD8A (CD8 alpha/beta Coreceptor)IL-2RA (Interleukin-2 receptor subunit alpha)CD3 (T-cell surface glycoprotein CD3)CD4 (T lymphocyte surface antigen)LFA-1 (Integrin αLβ2)
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