anti-T lymphocyte immunoglobulin

Anti-T lymphocyte immunoglobulin (also known as antithymocyte globulin or ATG) is a polyclonal antibody preparation obtained from the serum of animals (typically rabbits or horses) immunized with human T lymphocytes or thymocytes. It acts as a potent immunosuppressive agent primarily by depleting circulating T cells through complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis. It is widely used in conditioning regimens prior to allogeneic hematopoietic stem cell transplantation (HSCT) to prevent graft-versus-host disease (GVHD) and graft rejection, as well as in solid organ transplantation for the prevention and treatment of acute rejection, and in the treatment of severe aplastic anemia.

Brand names

AtgamEquingamGrafalonThymoglobuline

Other names

ATGATLGanti-T-lymphocyte globulinanti-T-lymphocyte immunoglobulinantilymphocyte globulinantilymphocyte serumantithymocyte globulinantithymocyte immunoglobulin