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antibiotic-impregnated calcium sulfate
- Development stage
- Unknown
- Lead developer
- Biocomposites
- Modality
- Small Molecules, Device-based Delivery → Drug Delivery Systems
- Administration
- Implant
01
Overview
Antibiotic-impregnated calcium sulfate is a biodegradable biomaterial intervention being studied by the University of Washington for the treatment of open tibia fractures with sub-segmental bone loss. It consists of calcium sulfate (CaSO4) mixed with antibiotics to form a spacer that is implanted directly into bone defects. The material acts as an osteoconductive scaffold, providing a structure for new bone growth while simultaneously delivering high concentrations of antibiotics locally to prevent or treat infection. Unlike traditional PMMA (polymethylmethacrylate) spacers, calcium sulfate is resorbable, meaning it is gradually broken down and replaced by host bone, which may eliminate the need for a secondary surgical procedure to remove the spacer. This intervention is currently being evaluated in a Phase 4 clinical trial (NCT03042546) to determine its efficacy in preventing nonunion and reducing the need for additional surgeries.
- Other names
- calcium sulfate spacercalcium sulfate beadsCaSO4CaSO-4CaSO 4antibiotic-impregnated calcium sulfate
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