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antigen-antibody complex therapeutic hepatitis b vaccine
- Development stage
- Unknown
- Lead developer
- Fudan University
- Modality
- Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intramuscular (inferred From Typical Vaccine Administration)
01
Overview
The antigen-antibody complex therapeutic hepatitis B vaccine is a novel immunotherapeutic approach designed to enhance the immune response in chronic hepatitis B (CHB) patients. It consists of complexes formed between hepatitis B surface antigens (HBsAg) and their corresponding antibodies. The mechanism involves presenting these complexes to the immune system to break immune tolerance and stimulate both humoral and cellular immunity against HBV. This strategy aims to restore or boost the host’s ability to clear HBV infection by inducing specific antibody production and activating T cell responses[1][2]. The development of such vaccines has been pursued by several research groups in China, with some candidates having progressed through preclinical studies into early clinical trials[2].
- Other names
- 抗原抗体复合物型乙肝治疗性疫苗antigen-antibody complex type therapeutic hepatitis B vaccineimmune complex therapeutic HBV vaccine
02
Targets
HBsAg (Hepatitis B surface antigen)
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