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antilymphocyte serum
- Development stage
- Phase 2
- Lead developer
- Pfizer
- Modality
- Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Antilymphocyte serum (ALS) is a serum containing gamma-globulins which are antibodies against lymphocyte antigens. It is primarily used as an immunosuppressive agent in organ transplantation to prevent rejection and in the treatment of aplastic anemia. The mechanism of action involves targeting lymphocyte surface proteins, causing rapid clearance of antibody-lymphocyte complexes by the reticuloendothelial system, which leads to selective ablation of recirculating lymphocytes. This results in decreased numbers of T lymphocytes involved in both cell-mediated and humoral immunity.
- Brand names
- AtgamLymphoser Berna
- Other names
- ALGAntilymphocyte globulinAntilymphocyte immunoglobulinLymphocyte immune globulin
02
Targets
PTPRC (Receptor-type tyrosine-protein phosphatase C)ATRN (Attractin)CD6
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