Drug intelligence / Profile preview

Antineoplaston A3

Development stage
Unknown
Lead developer
Burzynski Research Institute
Modality
Peptides, Small Molecules
Administration
Intravenous
01

Overview

Antineoplaston A3 is a peptide-based small molecule derivative developed by the Burzynski Clinic for the treatment of various cancers. It belongs to a class of compounds known as antineoplastons, which were originally identified and isolated from human urine and blood by Dr. Stanislaw Burzynski. The drug is administered via intravenous injection and is proposed to act as a "biochemical corrector" or "molecular switch" that normalizes the phenotype of neoplastic cells by modulating gene expression and signal transduction pathways. Despite being the subject of numerous Phase 1 and Phase 2 clinical trials over several decades, Antineoplaston A3 and related compounds remain highly controversial within the oncology community, as their efficacy and safety have not been established in large-scale, randomized Phase 3 trials, and they have not received regulatory approval from the FDA.

Other names
A3A-3A 3

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