Drug intelligence / Profile preview

antioxidant + pregabalin

Development stage
Preclinical
Lead developer
Pfizer
Modality
Small Molecules
Administration
Oral
01

Overview

The combination of antioxidant and pregabalin is used for pain management in chronic pancreatitis. Pregabalin is a small molecule that acts as a calcium channel modulator, reducing neuropathic pain by binding to the alpha-2-delta subunit of voltage-gated calcium channels. Antioxidants (such as methionine, selenium, β-carotene, ascorbic acid, and α-tocopherol) are thought to reduce oxidative stress in pancreatic tissue. Clinical trials have shown that this combination significantly reduces pain intensity, decreases the need for non-opioid analgesics, lowers hospital admissions related to pain episodes, and improves patient satisfaction compared to placebo[1][2][4].

Other names
antioxidant-pregabalin combinationpregabalin and antioxidants
02

Targets

CACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)CACNA2D2 (α2δ-2)

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