Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
antisense oligonucleotides against GSK3β
- Development stage
- Preclinical
- Modality
- Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Parenteral
01
Overview
Antisense oligonucleotides against GSK3β (AS-GSK3β) are antisense morpholino-oligonucleotides designed to knock down the expression of glycogen synthase kinase 3 beta (GSK3β). In preclinical models, local intrapancreatic administration of AS-GSK3β has been shown to promote both endocrine (beta cell) and exocrine (acinar cell) pancreatic regeneration. This knockdown prevents GSK3β from negatively regulating the Wnt/β-catenin and PI3K/Akt pathways, suggesting potential therapeutic applications in diabetes and pancreatitis.
- Other names
- antisense morpholino-oligonucleotides against GSK3βantisense oligonucleotides directed against GSK3βGSK3β antisense oligonucleotides
02
Targets
GSK3 (Glycogen synthase kinase 3 beta)
Beyond the preview
Go deeper on antisense oligonucleotides against GSK3β.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on antisense oligonucleotides against GSK3β.