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antisense peptide nucleic acid
- Development stage
- Preclinical
- Modality
- MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Not Specified; Typically Would Involve Direct Injection Or Delivery Methods Tailored To The Target Tissue
01
Overview
Antisense peptide nucleic acids (PNAs) are synthetic nucleic acid analogs with a neutral N-(2-aminoethyl) glycine backbone, known for their stability and resistance to enzymatic degradation. They function as antisense oligonucleotides by binding to complementary RNA sequences, thereby inhibiting gene expression. PNAs have been explored for therapeutic applications against various diseases, including infections, neurodegenerative diseases, and cancer.
- Other names
- Antisense PNAsPNA-based antisense oligonucleotides
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