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antithrombin gamma
- Development stage
- Phase 3
- Lead developer
- Kyowa Kirin
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
Antithrombin gamma is a recombinant form of human antithrombin developed as an alternative to plasma-derived antithrombin for the treatment and prevention of coagulation disorders such as disseminated intravascular coagulation (DIC) and antithrombin III deficiency. It acts primarily by inhibiting thrombin and other serine proteases in the coagulation cascade, including factors IXa, Xa, XIa, and XIIa. This inhibition prevents excessive clot formation. Antithrombin gamma is produced using genetic recombination technology to provide a virus-free alternative to plasma-derived products. The drug has been investigated in clinical trials for DIC and early onset severe preeclampsia[2][3][4][8].
- Brand names
- Acoalan
- Other names
- antithrombin III recombinantKW-3357KW3357KW 3357Acoalan
02
Targets
Coagulation Factor IXaF10 (Factor Xa)F2 (Thrombin)FXIIa (Coagulation Factor XIIa)Factor XIa
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