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antithymocyte globulin rabbit
- Development stage
- Approved
- Lead developer
- Sanofi
- Modality
- Recombinant Proteins and Enzymes, Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Antithymocyte globulin (rabbit) is a purified, pasteurized polyclonal antibody preparation derived from rabbits immunized with human T lymphocytes. It acts as an immunosuppressant by binding to multiple T-cell surface antigens, leading to the depletion of T lymphocytes through complement-mediated cytotoxicity and apoptosis. This results in suppression of the host immune response, making it effective for both prophylaxis and treatment of acute rejection in kidney transplant recipients. The drug is used in conjunction with other immunosuppressive agents and is administered intravenously[1][3][5][6].
- Brand names
- Thymoglobulin
- Other names
- antithymocyte immunoglobulin rabbitanti-thymocyte globulin rabbitATG rabbit
02
Targets
FCGR3B (Fc gamma receptor III)
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