antituberculous therapy + steroids

A combination regimen consisting of antituberculous therapy (typically including drugs such as isoniazid, rifampicin, pyrazinamide, and ethambutol) together with corticosteroids (such as prednisone or prednisolone). This combination is used primarily for specific forms of tuberculosis where inflammation contributes significantly to morbidity and mortality—most notably tuberculous meningitis, pericardial tuberculosis, and severe pleural disease. The mechanism involves the antimycobacterial action of the core anti-TB drugs combined with the anti-inflammatory and immunosuppressive effects of corticosteroids. Corticosteroids reduce tissue damage caused by excessive host immune response to Mycobacterium tuberculosis antigens. Evidence supports improved outcomes in certain TB complications when steroids are added to standard anti-TB regimens[1][2][3].

Other names

ATT + oral steroid