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antiviral lactobacilli throat spray

Development stage: Discontinued
Lead developer: Antwerp University Hospital
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Intranasal

Overview

Antiviral lactobacilli throat spray is an investigational microbiome therapy developed by the University Hospital, Antwerp. [3, 5] It consists of a throat spray containing three selected strains of Lactobacillaceae, a type of probiotic bacteria, with known broad antiviral properties. [3, 6] The therapy is being studied for its potential to reduce the symptoms and severity of COVID-19 in outpatients with mild to moderate symptoms and to prevent the transmission of the SARS-CoV-2 virus. [2, 6] The proposed mechanism involves modulating the respiratory tract microbiome to inhibit viral infection and disease progression through various actions, including direct antiviral activity and enhancement of the epithelial barrier. [3, 4]

Other names: microbiome spray

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