antrafenine

Antrafenine is a phenylpiperazine derivative and small molecule drug developed in the late 1970s as a non-narcotic analgesic and anti-inflammatory agent, with efficacy similar to naproxen. Its primary mechanism of action is believed to be inhibition of cyclooxygenase (COX) enzymes, specifically both COX-1 (prostaglandin G/H synthase 1) and COX-2 (prostaglandin G/H synthase 2), leading to reduced prostaglandin synthesis. This results in anti-inflammatory and analgesic effects. Antrafenine was studied for the treatment of mild to moderate pain and osteoarthritis but has largely been replaced by newer drugs due to limited use. It shows long duration of action and good tolerance in pharmacological studies[1][2][3][5][7].

Brand names

Stakane

Other names

2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl 2-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoate