Drug intelligence / Profile preview

antrocaryon micraster seed extract

Development stage
Preclinical
Lead developer
Centre for Plant Medicine Research
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Antrocaryon micraster seed extract is a botanical extract derived from the seeds of the *Antrocaryon micraster* tree, a member of the Anacardiaceae family native to tropical rainforests and utilized in African traditional medicine. The extract is rich in polyphenols and phytosterols, which contribute to its demonstrated antiarthritic and antioxidant properties in preclinical models. Research conducted primarily by academic institutions, such as the Centre for Plant Medicine Research in Ghana, indicates that the extract and its aqueous fraction (ASEA) significantly inhibit oxidative stress, protein denaturation, and the infiltration of inflammatory cells. In animal models of rheumatoid arthritis, it has shown efficacy in reducing paw edema, synovium damage, and pannus formation, suggesting potential for development as a natural therapeutic for inflammatory joint diseases.

Other names
Antrocaryon micraster seed extract

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