antrocin

Antrocin is a **naturally occurring sesquiterpene lactone** isolated primarily from the medicinal mushroom *Antrodia cinnamomea*. It has demonstrated **antiproliferative effects against multiple cancer cell types** (including breast, lung, prostate, and bladder cancers), exerting its effects by inhibition of tumor-promoting signaling pathways such as **PI3K/AKT, MAPK, JAK2/STAT3, IGF-1R, β-catenin, Notch1, and Akt**[1][2][3][8][10]. Preclinical studies show it can sensitize cancer cells to radiotherapy and potentiate the effect of chemotherapeutics like paclitaxel[2][3]. Antrocin also exhibits strong anti-oxidant and antimutagenic activities[1]. It has been evaluated for genotoxicity and oral toxicity in animal studies, showing a lack of significant toxicity at therapeutic reference doses[1]. Synthetic routes for antrocin as well as its isolation from fungal sources have been described[1][6][10][11].