Drug intelligence / Profile preview

antrodia salmonea

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

**Antrodia salmonea** is a medicinal fungus indigenous to Taiwan, traditionally used in folk medicine. It is known for its potential anticancer, anti-inflammatory, and antihypertensive activities. Bioactive compounds in Antrodia salmonea include triterpenoids and antrocins, which contribute to its pharmacological effects. Mechanistically, it induces apoptosis in various cancer cell lines, including colon and prostate cancer, through increased reactive oxygen species (ROS), activation of caspase pathways (notably caspase-3), PARP cleavage, cell cycle arrest, and regulation of p53 and androgen receptor signaling. It also demonstrates notable anti-inflammatory activity and potential inhibition of angiotensin-converting enzyme 2 (ACE2), suggesting utility in viral entry inhibition. The extract is used in complementary and alternative medicine for various conditions, such as diarrhea, abdominal pain, hypertension, and potentially cancer[1][2][3].

Other names
ASAntrodia salmonea extract
02

Targets

AR (Adrenergic receptors)CASP3 (Caspase-3)TP53 (Cellular Tumor Antigen p53 R175H)ACE2 (Angiotensin-converting enzyme 2)PARP1 (Poly (adp-ribose) polymerase 1)

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