Drug intelligence / Profile preview

anzutresgene autoleucel

Development stage
Phase 3
Lead developer
Immatics
Modality
TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
Administration
Intravenous
01

Overview

Anzutresgene autoleucel is a genetically modified autologous T cell therapy classified as a T-cell receptor (TCR) gene therapy. It uses a patient's own T cells, which are harvested and genetically engineered to express a specific T-cell receptor targeting a cancer-associated antigen. This process enables the infused T cells to recognize cancer cells expressing that antigen and attack them, functioning as a form of targeted cellular immunotherapy. Specific information on the targeted antigen, mechanism, developer, indications, and approval status for anzutresgene autoleucel is not found in the provided search results; however, the drug has a validated record in the FDA UNII database, indicating it is recognized as a distinct pharmaceutical entity[8].

Brand names
ACTengine
Other names
ACTengine IMA203 TCR-TACTengine IMA203 cell therapyImmatics ACTengine IMA203
02

Targets

HLA-A*02 (Human leukocyte antigen A*02 complexed peptide)

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