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aomexone sodium
- Development stage
- Unknown
- Lead developer
- Zhejiang Xianju Pharmaceutical
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Aomexone sodium is a modified γ-cyclodextrin derivative developed by Zhejiang Xianju Pharmaceutical as a selective relaxant binding agent (SRBA). It is specifically designed for the rapid reversal of neuromuscular blockade (NMB) induced by steroidal neuromuscular blocking agents, such as rocuronium and vecuronium. The drug functions by encapsulating the molecules of the neuromuscular blocking agent in the plasma in a 1:1 ratio, which lowers the free concentration of the blocker and promotes its dissociation from nicotinic acetylcholine receptors at the neuromuscular junction. This mechanism allows for a faster recovery of muscle function compared to traditional reversal agents like neostigmine. Aomexone sodium is currently undergoing Phase 3 clinical evaluation in China for the reversal of rocuronium-induced neuromuscular blockade.
- Other names
- aomexone奥美克松钠
02
Targets
Muscle-type nicotinic acetylcholine receptor
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