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AP747
- Development stage
- Preclinical
- Lead developer
- Aix-Marseille University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
- Administration
- Intravenous
01
Overview
AP747 (apelin-F13A-NODAGA) is a peptide-based PET radiotracer precursor designed to target the APJ receptor (apelin receptor), which is overexpressed in tissues undergoing pathological angiogenesis and cell proliferation. When radiolabeled with gallium-68 to form [68Ga]Ga-AP747, it serves as a diagnostic imaging agent for detecting, measuring, and monitoring angiogenesis and vasculogenesis in conditions such as cerebral ischemia-reperfusion (ischemic stroke), hindlimb ischemia, and colon adenocarcinoma. Developed by Aix-Marseille University, INSERM, and Assistance Publique - Hôpitaux de Marseille, [68Ga]Ga-AP747 has demonstrated high radiochemical purity, excellent serum stability, and superior target-to-background ratio compared to traditional integrin-targeting tracers like [68Ga]Ga-RGD2 in preclinical models.
- Other names
- [67Ga]Ga-AP747[68Ga]Ga-AP747Apelin-F13A-NODAGAApelin-F-13A-NODAGAApelin-F 13A-NODAGA
02
Targets
APLNR (Apelin receptor)
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