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APA-01
- Development stage
- Preclinical
- Lead developer
- PharmAla Biotech
- Modality
- Small Molecules
01
Overview
APA-01 is a novel small molecule phenethylamine derivative developed by PharmAla Biotech. It is designed as a potent entactogen with an improved safety pharmacology profile compared to MDMA. Mechanistically, APA-01 acts as a 5-HT1A receptor agonist, a feature that distinguishes it from traditional MDMA and potentially expands its therapeutic applications. The compound is intended to promote the regrowth of neuronal connections in damaged brain regions, suggesting potential utility in treating neurological disorders such as traumatic brain injury (TBI) and stroke. Additionally, it is being explored for neuropsychiatric conditions, including fear disorders and psychological trauma. As of late 2024, APA-01 is in preclinical development, with animal research data highlighting its MDMA-like effects without the associated safety concerns of the parent compound.
- Other names
- (R)-2-[(2H-1,3-Benzodioxol-5-YL)Methyl]Pyrrolidine
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))
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