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APH-2501
- Development stage
- Preclinical
- Lead developer
- Aphios
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
APH-2501 is an investigational drug being developed by Aphios for the treatment of Multiple Sclerosis (MS). It is a nanotechnology-based formulation of Bryostatin-1, a macrocyclic lactone naturally derived from the marine bryozoan *Bugula neritina*. The drug functions as a potent modulator of Protein Kinase C (PKC), a family of enzymes that play a critical role in cellular signaling, immune response, and neuroprotection. In the context of Multiple Sclerosis, APH-2501 is designed to cross the blood-brain barrier more effectively through Aphios's proprietary nanosome delivery technology. Its therapeutic potential lies in its ability to reduce neuroinflammation and promote neuroprotection by modulating PKC isoforms, which may help prevent the axonal degradation and demyelination characteristic of the disease.
- Other names
- Bryostatin-1Bryostatin1Bryostatin 1
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