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APHD-006
- Development stage
- Unknown
- Lead developer
- Aphaia Pharma
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
APHD-006 is a proprietary oral glucose formulation developed by Aphaia Pharma, designed for targeted release in discrete parts of the small intestine. The drug aims to restore endogenous nutrient-sensing signaling pathways and stimulate the release of a broad spectrum of enteric hormones—including glucagon-like peptide 1 (GLP-1), peptide tyrosine-tyrosine (PYY), glicentin, and oxyntomodulin (OXM)—that regulate appetite, hunger, satiety, glucose metabolism, and energy expenditure. This mechanism is intended to induce weight loss and improve metabolic health in individuals with obesity or prediabetes. APHD-006 specifically refers to the 6g dose formulation used twice daily in clinical trials[1][2][3][4][5][7].
- Other names
- distal jejunal-release dextrose beads
02
Targets
GLP1R (GLP-1R)PYY receptor (Peptide YY receptor family)
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