Drug intelligence / Profile preview

apis mellifera venom

Development stage
Phase 4
Lead developer
Stallergenes Greer
Modality
Peptides, Recombinant Proteins and Enzymes
Administration
Subcutaneous, Intradermal, Topical, Intramuscular, Intraarticular
01

Overview

Apis mellifera venom, or honey bee venom, is a complex biological substance containing various bioactive peptides and enzymes, most notably melittin, apamin, and phospholipase A2. It is primarily developed as a purified, standardized preparation for therapeutic use. In clinical settings, it is being investigated for its anti-inflammatory and analgesic properties in conditions such as osteoarthritis and multiple sclerosis, and for its neuroprotective potential in Parkinson's disease. The venom's mechanism of action includes the modulation of inflammatory cytokines and the blockade of small conductance calcium-activated potassium (SK) channels. Companies like Apimeds Pharmaceuticals US and Allergopharma are leading the clinical development of purified bee venom products for systemic and local administration.

Brand names
Apitox
Other names
Honey bee venomBee venom蜂毒
02

Targets

MRC1 (Mannose Receptor C-type 1)

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