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Apizolin-Z
- Development stage
- Unknown
- Lead developer
- Amman Pharmaceutical Industries
- Modality
- Small Molecules
- Administration
- Ophthalmic
01
Overview
Apizolin-Z is an over-the-counter ophthalmic solution developed by Amman Pharmaceutical Industries (under the Apisal line) for the temporary relief of eye redness, swelling, and minor irritations caused by environmental factors such as dust, wind, smoke, swimming, or prolonged visual work. It is a fixed-dose combination containing naphazoline hydrochloride, a rapid-acting sympathomimetic vasoconstrictor, and zinc sulfate, a mild astringent. Naphazoline stimulates alpha-adrenergic receptors on conjunctival blood vessels, causing vasoconstriction and reducing congestion, while zinc sulfate precipitates proteins on the ocular surface to clear mucus and soothe irritation.
- Brand names
- Apizolin-ZClear Eyes ACRClear Eyes Cooling Comfort Itchy Eye ReliefClear Eyes Maximum Strength Itchy Eye ReliefClear Eyes Seasonal ReliefNaphalonNazinVasoClear A
- Other names
- naphazoline + zinc sulfatenaphazoline hydrochloride + zinc sulfatenaphazoline/zinc sulfate
02
Targets
ADRA2B (α2B)ADRA1D (α1D)ADRA2A (α2A)ADRA1B (α1B)ADRA2C (α2C)ADRA1A (α1A)
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