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APL-3007 + APL-2
- Development stage
- Phase 2
- Lead developer
- Apellis Pharmaceuticals
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Peptides
- Administration
- Intravitreal, Subcutaneous
01
Overview
**APL-3007 + APL-2** is an investigational co-administration regimen from Apellis for **geographic atrophy secondary to age-related macular degeneration**. It combines subcutaneous APL-3007, a small interfering RNA designed to reduce production of complement component 3, with intravitreal pegcetacoplan, the C3-targeting cyclic peptide marketed as SYFOVRE and previously known as APL-2. The regimen is intended to provide more comprehensive inhibition of complement activity affecting the retina and choroid. It is being evaluated in a randomized, placebo-controlled Phase 2 study.
- Other names
- APL-3007 + pegcetacoplanAPL-3007 + SYFOVREpegcetacoplan + APL-3007SYFOVRE + APL-3007
02
Targets
C3C3b (Complement Component 3b)
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