aplyronine a

Aplyronine A is a highly potent antitumor macrolide compound originally isolated from the sea hare Aplysia kurodai. It exhibits strong cytotoxic activity, primarily through its unique mechanism of disrupting cytoskeletal dynamics by dual targeting of both actin and tubulin. Aplyronine A induces protein-protein interactions between actin and tubulin, inhibits the polymerization of G-actin to F-actin, and depolymerizes F-actin to G-actin. This results in disruption of cell division and potent antimitotic effects. Its picomolar-level cytotoxicity and novel mode of action make it an attractive candidate for development as an anticancer agent, including as a payload for antibody–drug conjugates in cancer chemotherapy[2][3][4][5][6][7].