Drug intelligence / Profile preview

apocyni veneti folium extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Apocyni veneti folium extract is a natural product derived from the leaves of *Apocynum venetum* L., a plant in the Apocynaceae family commonly known as Luobumaye in Traditional Chinese Medicine. The extract is characterized by a high concentration of bioactive flavonoids, including quercetin, rutin, isoquercetin, hyperoside, and kaempferol, alongside organic acids and amino acids. It is primarily researched for its cardioprotective, antihypertensive, and neuroprotective properties. Mechanistically, the extract has been shown to modulate the PI3K/Akt/GSK-3β and AMPK signaling pathways, inhibit acetylcholinesterase (AChE) activity, and reduce oxidative stress and neuroinflammation. Recent studies highlight its potential in mitigating Alzheimer's disease pathology by targeting the gut-brain axis and reducing amyloid-β accumulation. It is typically utilized as a dietary supplement or traditional herbal remedy rather than a regulated pharmaceutical drug.

Other names
Apocynum venetum leaf extractLuobumaye extractVenetum leaf extract
02

Targets

AKT (RAC-alpha serine/threonine-protein kinase)AMPK (Adenosine monophosphate–activated protein kinase)AR (Adrenergic receptors)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)AcetylcholinesteraseGSK3 (Glycogen synthase kinase 3 beta)

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