apocynum venetum extract

Apocynum venetum extract is a botanical extract derived from the leaves of Apocynum venetum, a perennial plant found in Asia, Europe, and North America. It is known for its wide range of pharmacological activities, including **antidepressant**, **anxiolytic**, **cardioprotective**, **antihypertensive**, **sedative**, **diuretic**, **sleep-promoting**, **anti-aging**, and **anti-inflammatory** effects[1][2][4][5]. The extract contains active flavonoids such as hyperoside, isoquercitrin, rutin, astragaloside, and quercetin. Mechanisms of action include inhibition of neuronal apoptosis (by regulating levels and activity of Bcl-2, Bax, caspase-3, caspase-9, cytochrome c, BDNF, and CREB)[1]; modulation of monoamine neurotransmitters including norepinephrine and dopamine[1]; cardioprotection via AKT/Bcl-2 signaling and reduction of doxorubicin-induced toxicity through modulation of gut microbiota and organic acids[2]; and reduction of blood pressure and cardiovascular risk[4]. It is used as a **dietary supplement** in Japan (notably as Venetron) and as a **phytopharmaceutical or herbal remedy** in China for insomnia, kidney disease, hypertension, heart palpitations, and mood disorders[3][4].

Brand names

Venetron

Other names

Apocynum venetum leaf extractAVLELuobuma extractRafuma extract