apohemoglobin-haptoglobin

**Apohemoglobin-haptoglobin** is an investigational two-protein biologic complex comprising apohemoglobin, a heme-depleted hemoglobin protein that binds free heme, and haptoglobin, a hemoglobin-binding plasma protein that supports clearance of cell-free hemoglobin. The complex is designed to simultaneously scavenge acellular hemoglobin and heme released during intravascular hemolysis, thereby reducing hemoglobin- and heme-driven vasoconstriction, oxidative stress, endothelial activation, inflammation, microvascular stasis, and vaso-occlusion. It has shown preclinical activity in mouse models of sickle cell disease and beta-thalassemia, including improvements in microvascular blood flow and cardiovascular parameters. Development reported publicly is preclinical and associated with University of California San Diego and The Ohio State University research groups.

Other names

apoHb+HpapoHb-Hpapohemoglobin-haptoglobinapohemoglobin-haptoglobin complex