Drug intelligence / Profile preview

apPHOTAC-II-2C

Development stage
Unknown
Lead developer
University of Pennsylvania
Modality
PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules
01

Overview

apPHOTAC-II-2C: sourced facts only. name: "This approach was extended to synthesize apPHOTAC-II-2C, the first nanomolar photoswitchable degrader of tumor-associated protein MTH1, establishing a promising synthetic approach for future PHOTAC development." [PMID:42807851]; target: "This approach was extended to synthesize apPHOTAC-II-2C, the first nanomolar photoswitchable degrader of tumor-associated protein MTH1, establishing a promising synthetic approach for future PHOTAC development." [PMID:42807851]; developer: "Department of Chemistry, School of Arts & Sciences, University of Pennsylvania Philadelphia PA USA [email protected]." [PMID:42807851]; modality: "This approach was extended to synthesize apPHOTAC-II-2C, the first nanomolar photoswitchable degrader of tumor-associated protein MTH1, establishing a promising synthetic approach for future PHOTAC development." [PMID:42807851]

02

Targets

NUDT1 (Nudix hydrolase 1)

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