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Apricot kernel oil is a natural, non-hormonal oil extracted from the seeds of *Prunus armeniaca*. In a clinical research context led by the University of Louisville, it is being evaluated as a non-hormonal alternative to vaginal estrogen for the management of genitourinary syndrome of menopause (GSM). The oil functions primarily as an emollient and lubricant, providing symptomatic relief for vaginal dryness and irritation by improving tissue hydration and barrier function. The specific Phase 4 study investigates its impact on the vaginal and urinary microbiome compared to conjugated equine estrogen (Premarin) in postmenopausal women, aiming to provide a safe alternative for those who cannot or prefer not to use hormonal therapies.
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