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Drug intelligence / Profile preview
Aprise
- Development stage
- Unknown
- Lead developer
- Merck
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Aprise is a brand of cyproheptadine, a first-generation antihistamine with significant antiserotonergic and anticholinergic properties. Manufactured by Emcee Pharmaceuticals, it is primarily formulated as a 2mg syrup. The drug functions by antagonizing H1 histamine receptors to alleviate allergic symptoms such as sneezing, itching, and watery eyes. Additionally, its potent antagonism of 5-HT2 serotonin receptors in the hypothalamus makes it an effective appetite stimulant, used clinically to treat undernutrition, malnutrition, and failure to thrive. Due to its ability to cross the blood-brain barrier, common side effects include sedation, drowsiness, and dizziness. It is typically used with caution in patients with hepatic or renal impairment.
- Brand names
- Aprise
- Other names
- cyproheptadine hydrochloride
02
Targets
HTR2A (Serotonin receptor 5-HT2A)HTR2B (5-Hydroxytryptamine Receptor 2B)HTR2C (5-hydroxytryptamine 2C receptor)HRH1 (Histamine H1 Receptor)
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