aprotinin

Aprotinin is a polypeptide and broad-spectrum serine protease inhibitor originally derived from bovine lung. It is primarily used to reduce perioperative blood loss and the need for blood transfusion in patients undergoing complex surgeries such as cardiopulmonary bypass during coronary artery bypass graft surgery. Aprotinin acts by inhibiting several serine proteases, including trypsin, chymotrypsin, plasmin, and kallikrein. Its inhibition of kallikrein leads to reduced formation of factor XIIa, thereby suppressing both the intrinsic coagulation pathway and fibrinolysis. By also inhibiting plasmin, aprotinin slows down fibrinolysis independently. These actions result in decreased bleeding risk during surgery by maintaining hemostatic balance without increasing thrombosis risk. Additionally, aprotinin has anti-inflammatory effects through modulation of neutrophil activation and cytokine release[1][2][3][4][5]. **Developers:** University of Munich (discovery), Bayer (original developer) **Manufacturers:** Bayer

Brand names

Trasylol

Other names

bovine pancreatic trypsin inhibitorAPR