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AQL-Naltrexone
- Development stage
- Preclinical
- Lead developer
- Plumb Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Subcutaneous
01
Overview
AQL-Naltrexone (AQL-Nal) is an extended-release, liposome-based formulation of naltrexone developed by Plumb Pharmaceuticals for the treatment of Opioid Use Disorder (OUD). The drug is designed as a subcutaneous injection that utilizes Plumb's proprietary AQL technology to provide sustained release of the active ingredient over multiple months. As a non-selective opioid receptor antagonist, naltrexone blocks the euphoric effects of exogenous opioids and reduces cravings, thereby assisting in the prevention of relapse in patients with opioid dependence. This formulation aims to improve patient compliance by reducing the frequency of administration compared to existing daily oral or monthly injectable naltrexone products.
- Other names
- AQL-Naltrexone
02
Targets
DOR (Opioid Receptor Delta 1)KOR (Kappa opioid receptor)MOR (Mu opioid receptor)SIGMAR1 (Sigma non-opioid intracellular receptor 1)
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