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AqT-MMAE
- Development stage
- Preclinical
- Lead developer
- AqueaTether Therapeutics
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
AqT-MMAE is a modified form of the potent tubulin inhibitor monomethyl auristatin E (MMAE), developed by AqueaTether Therapeutics and CellMosaic. It utilizes the AqueaTether (AqT) platform, which incorporates super-hydrophilic linkers derived from sugar alcohols to improve the water solubility and reduce the aggregation of the highly hydrophobic MMAE payload. This technology is designed to enable higher drug-to-antibody ratios (DAR) in antibody-drug conjugates (ADCs) while maintaining stability and biocompatibility. Upon reaching the target cancer cell, the MMAE is released via a cleavable ester bond to exert its antimitotic effect by inhibiting tubulin polymerization, leading to cell cycle arrest and apoptosis.
- Other names
- monomethyl auristatin E-AqueaTetherAqT-monomethyl auristatin E
02
Targets
TUBB (Tubulin (alpha and beta subunits))
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