Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
aqueous extract of Salvia miltiorrhiza Bge. f. alba
- Development stage
- Preclinical
- Lead developer
- Shandong University of Traditional Chinese Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
The aqueous extract of Salvia miltiorrhiza Bge. f. alba (AESM) is a botanical preparation derived from the white-flowered variant of the traditional Chinese medicinal herb *Salvia miltiorrhiza* (Danshen). It contains water-soluble bioactive compounds such as salvianolic acids and danshensu. Research, primarily conducted by academic institutions like the Shandong University of Traditional Chinese Medicine, has focused on its potential therapeutic effects in pulmonary hypertension (PH). In preclinical rat models, AESM has demonstrated the ability to reduce mean pulmonary artery pressure, improve right ventricular function, and attenuate vascular remodeling. Its mechanism of action involves protecting the vascular endothelium from injury, modulating the balance of vasoactive substances (increasing nitric oxide and prostacyclin while decreasing endothelin-1 and thromboxane A2), and reducing levels of transforming growth factor-beta 1 (TGF-β1).
- Other names
- Salvia miltiorrhiza Bge. f. alba extractwhite-flowered Danshen extract
02
Targets
SMAD3 (SMAD family member 3)ET-1 (Endothelin-1)TYMP (Thymidine phosphorylase)NOS3 (eNOS)PTGIR (Prostanoid IP Receptor)
Beyond the preview
Go deeper on aqueous extract of Salvia miltiorrhiza Bge. f. alba.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on aqueous extract of Salvia miltiorrhiza Bge. f. alba.