AR-AO-14418

AR-AO-14418 is a potent and selective small molecule inhibitor of glycogen synthase kinase 3 beta (GSK3β). It acts as an ATP-competitive inhibitor with high specificity for GSK3β (IC50 ≈104 nM; Ki ≈38 nM), showing minimal activity against other kinases such as cdk2 or cdk5. The compound has been used extensively in preclinical research to study the role of GSK3β in various diseases including diabetes and Alzheimer’s disease. In animal models (e.g., forced swim test in rats), it has demonstrated behavioral effects consistent with antidepressant drugs. There are no approved clinical indications or ongoing clinical trials for this compound; its use is limited to experimental and laboratory research[1][2][4][6].

Other names

N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea