Drug intelligence / Profile preview

AR001

Development stage
Preclinical
Lead developer
Aeon Respire
Modality
Small Molecules
01

Overview

AR001 is a code name associated with two distinct experimental therapeutic agents. The first is a selective **adenosine A1 receptor agonist** (CAS 681475-23-0) that has demonstrated hypnotic efficacy in animal models, suggesting potential for the treatment of **insomnia**. It functions by increasing the expression and mRNA levels of the adenosine A1 receptor in the hypothalamus. The second is a preclinical-stage drug being developed by **Aeon Respire** for the treatment of **cystic fibrosis** and other respiratory, immune, and digestive system disorders. This version of AR001 is designed to address mucus-related pathologies and inflammation in the lungs.

Other names
N6-cyclohexyl-2'-O-methyladenosine
02

Targets

ADORA1 (Adenosine receptor A1 subtype)ANO1 (Anoctamin-1)

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