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ARB-1740
- Development stage
- Discontinued
- Lead developer
- Arbutus Biopharma
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
**ARB-1740** is a second-generation, clinical-stage RNA interference (RNAi) therapeutic developed by Arbutus Biopharma for chronic hepatitis B (CHB) infection. It consists of three small interfering RNAs (siRNAs) formulated in lipid nanoparticles (LNP) for targeted hepatic delivery, enabling pan-genotypic silencing of HBV antigens including HBsAg, HBeAg, HBcAg, and HBV genome transcripts via post-transcriptional gene silencing. Preclinical studies demonstrated potent reductions in HBV viremia (2.3 log10), HBsAg (2.6 log10), and HDV viremia (1.6 log10) in humanized mouse models; it advanced to Phase II trials but was discontinued due to suboptimal efficacy.[1][2][3][4][5]
02
Targets
HBV RNA (Hepatitis B virus RNA)
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