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arbutin + tretinoin + triamcinolone
- Development stage
- Unknown
- Lead developer
- Marksans Pharma
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Topical
01
Overview
This is a topical combination of three active ingredients: arbutin, tretinoin, and triamcinolone. Arbutin is a glycosylated hydroquinone derivative that acts as a competitive inhibitor of tyrosinase, suppressing melanogenesis and reducing skin hyperpigmentation[1][2][4]. Tretinoin is an all-trans retinoic acid (a vitamin A derivative) that modulates epithelial cell growth and differentiation, commonly used in acne and hyperpigmentation disorders. Triamcinolone is a synthetic corticosteroid with anti-inflammatory properties. This combination may be used in dermatology to treat conditions involving hyperpigmentation, inflammation, or abnormal keratinization.
- Other names
- arbutosideursinuvasol
02
Targets
GR (Glucocorticoid receptor)RARA (Retinoic acid receptor alpha)TYR (Tyrosinase)
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