Archexin-Nano

Archexin-Nano is a **nanoparticle-based formulation** of RX-0201 (Archexin), an antisense oligonucleotide specifically targeting Akt-1 mRNA, under development for cancer treatment. This formulation employs folate receptor-targeted lipid-coated albumin nanoparticles (F-LCAN) to deliver RX-0201, aiming to enhance and prolong the anti-tumor activity and pharmacokinetic profile compared to standard Archexin. Archexin itself is an antisense oligonucleotide that binds Akt-1 mRNA, reducing expression of the Akt-1 protein kinase, which is associated with cancer cell proliferation, survival, angiogenesis, and drug resistance. Preclinical studies of Archexin-Nano have demonstrated increased potency and extended duration of action in vitro and in vivo cancer models, suggesting potential for improved therapeutic delivery and efficacy of antisense agents in oncology[13].

Brand names

Archexin-Nano

Other names

RX-0201 nanoparticleRX0201 nanoparticleRX 0201 nanoparticleF-LCAN RX-0201Folate Receptor-Targeted Lipid Coated Albumin Nanoparticles ArchexinArchexin-nano