Drug intelligence / Profile preview

arctium lappa chloroform extract

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

*Arctium lappa* chloroform extract is a non-polar fraction derived from the roots of the Burdock plant (*Arctium lappa* L.). This specific extract is often studied for its high concentration of lipophilic bioactive compounds, such as lignans (e.g., arctigenin and arctiin), which possess anti-inflammatory, antioxidant, and anti-atherosclerotic properties. In preclinical models, such as high-fat diet-induced atherosclerosis in quail, the chloroform extract has demonstrated protective effects by modulating lipid profiles and reducing vascular plaque formation. It is primarily used in ethnopharmacological research and as a component in dietary supplements rather than as a regulated pharmaceutical drug.

Other names
burdock root chloroform extractArctium lappa L. root chloroform extract
02

Targets

ATP4A (Potassium–transporting ATPase alpha chain 1)TLR4 (Toll-like receptor 4)NF-κBNFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)

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